Dr. Mark Souweidane today treated the final patient in his Phase I clinical trial of convection-enhanced delivery (CED) for diffuse intrinsic pontine glioma (DIPG). The trial, which had enrolled 31 patients over the past four years, was designed to test the safety of CED as a means of delivering a cancer-fighting drug directly to the site of a DIPG tumor. (More about the DIPG trial.)
The trial received FDA approval in late 2011, and the first patient was treated in May 2012. (Read “Cheering for Caitlin,” a profile of the first patient.) Since then, 30 children have received infusions of a therapeutic agent called 124I-8H9, which consists of the 8H9 antibody (produced by mice and effective against many kinds of tumors) combined with the radioactive substance 124I. The dosage of the drug was increased over the course of the trial, also testing safety, but no dose-limiting side effects occurred in any patient.
The infusions, which were done at Memorial Sloan Kettering Cancer Center, were able to deliver the drug directly to the brain stem tumor and were not blocked by the body’s protective blood-brain barrier, which normally prevents chemotherapy drugs from crossing from the bloodstream into the brain in sufficient concentrations to attack a tumor. In this trial, Dr. Souweidane was able to achieve concentrations of 1,000 times or more than what can be achieved with IV chemotherapy. He was also able to design and test new ways to measure those concentrations at the tumor site and monitor how long the drug stayed in the tumor.
Dr. Souweidane and his team will spend the next several months evaluating the data and preparing the results for publication. In the meantime, researchers in the Children’s Brain Tumor Project laboratory have been working to pave the road for the next stages of the trial. Other drugs and drug combinations are being tested to determine what the best agents are to infuse, and at what dose levels. DIPG cell lines are also being grown in the lab, providing a rich source of information about how the tumor mutates over time and responds to different treatments in vitro as well as in animal models. (More about the Children’s Brain Tumor Project.)
Read the blog post written by Dr. Souweidane after he treated the final patient in the trial, click the link below www.weillcornellbrainandspine.org/dipg-new-beginning
The National Coalition of Latino Officers Foundation New York and New Jersey Invite you to Their Fundraiser and Awards Dinner
two of the honorees this evening will be Cristian Rivera Foundation Board of Director Darlene Rodriguez Anchor of the award winning NBC’s “Today In New York” & Cristian Rivera Foundation Committee Friend Eddie Caban Inspector, New York City Police Department
Friday June 10, 2016 7pm to 11pm
Fiesta Banquets 255 State Highway 17 South Wood-Ridge, NJ 07075
Tickets $110 p/p Three Course Dinner and Open Bar all night Please reserve your table early to purchase your ticket please contact: Information: Tel: (800) 982-6256 or visit www.latino-officers.org/event-2238481
Follow here to read The New York Daily News article published Today Sat 11/14 which highlights The Cristian Rivera Foundation’s drive and dedication to find a cure for DIPG and the upcoming Gala Tues Nov 17th at the Broad Street Ballroom.
Bio Carlos J. Yepez, is a current VP Branch Manager with PNC Bank in West Windsor NJ and President of PNC Bank Latino Employee Resource Group in the Central NJ Market.
With Over 15 years of banking experience, Carlos has managed to make a positive impact on his clients overall financial well-being. He is a strong leader in the community and is always engaged in community events delivering brand awareness for PNC Bank and himself.
He is a father of two wonderful children Angelica and Noah and Husband to an Amazing Wife Brenda. Carlos is a Native New Yorker and currently resides in New Jersey. Being born in “El Barrio” he loved listening to all kinds of Latin Music especially Salsa. Carlos is the Lead Singer for Nelson Toress’ Grupo Decision a Bronx based Salsa Band and loves teaching his kids all about their culture through Latin Music.
Statement “Being asked to join the Cristian Rivera Foundation is a true honor. I never had the privilege of personally meeting Cristian Rivera but through his foundation I feel as if I already knew him. Through his pictures you can see the innocence and kind heart this young man had. Being a father myself I can’t fathom the thought of losing a child. I have had the pleasure of meeting John “Gungie” Rivera, Cristian’s father who has given me the opportunity to support the foundation as a committee member. The passion and drive that this foundation delivers is contagious. The goal of finding a cure for DIPG, Creating Awareness, and Delivering Support to those affected are impactful.”
“I am excited to become a part of the Cristian Rivera Foundation Family.”