Tag: Children

Dr. Souweidane Treats Final Patient in Groundbreaking DIPG Clinical Trial

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Dr. Mark Souweidane today treated the final patient in his Phase I clinical trial of convection-enhanced delivery (CED) for diffuse intrinsic pontine glioma (DIPG). The trial, which had enrolled 31 patients over the past four years, was designed to test the safety of CED as a means of delivering a cancer-fighting drug directly to the site of a DIPG tumor. (More about the DIPG trial.)

The trial received FDA approval in late 2011, and the first patient was treated in May 2012. (Read “Cheering for Caitlin,” a profile of the first patient.) Since then, 30 children have received infusions of a therapeutic agent called 124I-8H9, which consists of the 8H9 antibody (produced by mice and effective against many kinds of tumors) combined with the radioactive substance 124I. The dosage of the drug was increased over the course of the trial, also testing safety, but no dose-limiting side effects occurred in any patient.

The infusions, which were done at Memorial Sloan Kettering Cancer Center, were able to deliver the drug directly to the brain stem tumor and were not blocked by the body’s protective blood-brain barrier, which normally prevents chemotherapy drugs from crossing from the bloodstream into the brain in sufficient concentrations to attack a tumor. In this trial, Dr. Souweidane was able to achieve concentrations of 1,000 times or more than what can be achieved with IV chemotherapy. He was also able to design and test new ways to measure those concentrations at the tumor site and monitor how long the drug stayed in the tumor.

Dr. Souweidane and his team will spend the next several months evaluating the data and preparing the results for publication. In the meantime, researchers in the Children’s Brain Tumor Project laboratory have been working to pave the road for the next stages of the trial. Other drugs and drug combinations are being tested to determine what the best agents are to infuse, and at what dose levels. DIPG cell lines are also being grown in the lab, providing a rich source of information about how the tumor mutates over time and responds to different treatments in vitro as well as in animal models. (More about the Children’s Brain Tumor Project.)

Read the blog post written by Dr. Souweidane after he treated the final patient in the trial, click the link below www.weillcornellbrainandspine.org/dipg-new-beginning

Robert Vazquez, a proud committee member of the Cristian Rivera Foundation, authors a children´s book entitled “Next Stop, Yankee Stadium”.

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Whether you´re looking forward to or thinking back on your first Yankee game, “Next Stop, Yankee Stadium” captures the legacy and the excitement of attending a game at sports most coveted venue. Travel back in time with four childhood friends on their visit to Yankee Stadium.

You will be transported through the bustling city as the four friends make their way to the historic and impressive landmark. The city and stadium illustrations are brought to life by legendary Bronx Graffiti pioneers, TATS CRU. This book is a true Yankees adventure for all.

Help The Cristian Rivera Foundation
whenever you make a purchase

  • 1)Visit Smile.Amazon.Com
  • 2)Create an account and select “The Cristian Rivera Foundation” as the charity you would like to support.
  • 3)Select your items as you normally would and Amazon will make a small donation on your behalf.

No extra fees! You shop– you help us get closer to a cure for D.I.P.G.

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and help The Cristian Rivera Foundation

The Cristian Rivera Foundation attends the Second Annual Children’s Brain Tumor Project Family Council Meeting on Tuesday April 28th, 2015

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The Cristian Rivera Foundation who is one of the top donors of The Children’s Brain Tumor Project is proud to attend the Children’s Brain Tumor Project Second Annual Family Council Meeting Today Tuesday April 28th, 2015. It’s an honor to come together with other families and foundations who all share the same passion towards helping fund Dr. Mark Souweidane and all the other Doctors who work tirelessly towards finding a cure for inoperable brain tumors.