News & Press

Remembering Delaney Starcher

 

Happy 8th birthday to DIPG angel, Delaney Starcher born April 1st, 2004. “Laney Bug” was diagnosed on October 9th, 2008 at just over 4 years old and about a year later on December 1st, 2009 this little angel earned her wings. She won her battle and found her place in heaven, where she watches over her mom and step-dad, sisters and brother. Delaney was the uplifting spirit to all around her and we’re sure that will never change. Happy birthday, angel.

Remembering Isaiah Ryan Garza

 

Isaiah was a strong spirit that surrounded him with friends. He loved for others to be happy and wanted to make a difference in the world. We applaud his strong will to do so. Born on July 21st, 1992, Isaiah was 12 years old when he was diagnosed with DIPG and it was two years later, April 1st, 2006 that he became an angel. Our thoughts reach out to Isaiah’s family on this day. You will never be forgotten, Isaiah. We’re sure you’re doing wonderful things in heaven. Keep watching over and rest peacefully.

Local Charity Raises $10,000 for Cancer Research with Charity Performance of
Award-Winning Musical!

 

Local Charity Raises $10,000 for Cancer Research with Charity Performance of Award-Winning Musical! March 23, 2012—New York, NY—New York-based not-for-profit 501(c)(3) The Cristian Rivera Foundation raised $10,000 for a pioneering cancer trial at Memorial Sloan Kettering on Thursday, March 22 with a one-night-only charity performance of award-winning bilingual musical DC-7, The Roberto Clemente Story at the Puerto Rican Traveling Theatre.or more information on the Cristian Rivera Foundation, visit cristianriverafoundation.org

The Cristian Rivera Foundation Raises $10,000
with Successful Theater Event

 

The Cristian Rivera Foundation hosted a successful charity performance of award-winning bilingual musical DC-7, The Roberto Clemente Story on Thursday, March 22. The event, which included a two-hour red carpet event catered by Celebrity Chef and Cristian Rivera Foundation Committee Member Alex Garcia, the executive chef at Babalu Restaurant and Lounge in the Bronx, raised $10,000 toward Dr. Mark Souweidane’s pioneering clinical trials aimed at finding a cure for DIPG. Dr. Souweidane attended the performance and as he accepted the check live on stage from Cristian Rivera Foundation founder John “Gungie” Rivera and all of the committee members in attendance, he announced that his team is within weeks of treating the first patient. Among the night’s high-profile attendees were The Real Housewives of New Jersey star Danielle Staub and Cristian Rivera Foundation Committee Members sportscaster and humanitarian Roberto Clemente Jr., founder of the Puerto Rican Traveling Theatre Miriam Colon, businessman Elis Pacheco, founder and president of Metropolitan Recording Corporation Jerry Salerno, DJ Tedsmooth, music producer Aldo Marin, Red Entertainment Group founder Carlos Keyes, businessman Jeff Lavino, David Letterman Show staffer Karen Cerna, real estate agent Fulvia Lora, Bronx Base Builders founder William Padilla, information technology manager Steve Cox, X-Interactive Media founder Carlos Colon, philanthropist Dolores Catania.

Bilingual Musical to Host Charity Performance Benefiting the Cristian Rivera Foundation

On Thursday, March 22, DC-7 The Roberto Clemente Story will be hosting a special charity performance to benefit The Cristian Rivera Foundation. Cristian Rivera Foundation Founder John “Gungie” Rivera and Cristian Rivera Foundation Committee Members Ralph Mercado III and Miriam Colon are associate producers of the play, which is produced by Teatro SEA’s Manuel Moran.

The play stars Modesto Lacen as Roberto Clemente, the first Hispanic ever inducted into the Baseball Hall of Fame. Clemente was not only a baseball MVP but also a humanitarian and civil rights activist who died 40 years ago when his plane crashed on the way to helping earthquake victims in Nicaragua. Two of Clemente’s sons have raved about Lacen’s award-winning performance, as well as the entire production, which won six ACE awards including Best Musical.

“For this generation who never got to know my father, Modesto Lacen does a great job portraying him,” said Luis Roberto Clemente. “He resembles him a lot and with his singing especially, he gives an amazing performance.” Older brother Roberto Clemente Jr. added, “I have seen the show five times now and the whole cast does a wonderful job, but especially Modesto Lacen. I believe that he has truly transformed into my father, no doubt about it.”

Tickets for this special performance are $67.50


The performance begins at 8pm and will be preceded by red carpet arrivals and a cocktail reception from 6pm to 8pm with complimentary wine and hors d’oeuvres provided by Cristian Rivera Foundation Committee Member and Celebrity Chef Alex Garcia and Babalu Restaurant and Lounge in the Bronx.
For more information please call 212-779-2222.

Remembering Nathan Andrew Waggoner

 

Nathan, born August 18th, 1992 was a positive spirit, even after his diagnosis on May 8th, 2008 at the age of 16. He loved his job at an Omaha local Sporting Goods store where he was always around equipment for the sports he loved. He enjoyed boating, fishing, wakeboarding, snowboarding and kayaking. It was March 19th, 2010 when Nathan became an angel. Our thoughts are with his parents Jeff and Monica and his brother Nicholas always. Rest in peace, angel. Keep smiling.

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric
Diffuse Intrinsic Pontine Gliomas

“Two distinct transcriptional subclasses of DIPG with specific genomic alterations can be defined at diagnosis by oligodendroglial differentiation or mesenchymal transition, respectively…..Patients in this later group had a significantly worse outcome with an hazard ratio for early deaths, ie before 10 months, 8 fold greater that the ones in the other. The worse outcome of patients with the oligodendroglial type of tumors was confirmed on a series of 55 paraffin-embedded biopsy samples at diagnosis (median overall survival of 7.73 versus 12.37 months.”

Free Full Text- http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030313
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Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas. PLoS One. 2012;7(2):e30313. Epub 2012 Feb 28.Puget S, Philippe C, Bax DA, Job B, Varlet P, Junier MP, Andreiuolo F, Carvalho D, Reis R, Guerrini-Rousseau L, Roujeau T, Dessen P, Richon C, Lazar V, Le Teuff G, Sainte-Rose C, Geoerger B, Vassal G, Jones C, Grill J.

Source
Department of Neurosurgery, Necker-Sick Children Hospital, University Paris V Descartes, Paris, France.

Abstract
Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universaly fatal. No significant improvement has been made in last thirty years over the standard treatment with radiotherapy. To address the paucity of understanding of DIPGs, we have carried out integrated molecular profiling of a large series of samples obtained with stereotactic biopsy at diagnosis. While chromosomal imbalances did not distinguish DIPG and supratentorial tumors on CGHarrays, gene expression profiling revealed clear differences between them, with brainstem gliomas resembling midline/thalamic tumours, indicating a closely-related origin. Two distinct subgroups of DIPG were identified. The first subgroup displayed mesenchymal and pro-angiogenic characteristics, with stem cell markers enrichment consistent with the possibility to grow tumor stem cells from these biopsies. The other subgroup displayed oligodendroglial features, and appeared largely driven by PDGFRA, in particular through amplification and/or novel missense mutations in the extracellular domain. Patients in this later group had a significantly worse outcome with an hazard ratio for early deaths, ie before 10 months, 8 fold greater that the ones in the other subgroup (p = 0.041, Cox regression model). The worse outcome of patients with the oligodendroglial type of tumors was confirmed on a series of 55 paraffin-embedded biopsy samples at diagnosis (median OS of 7.73 versus 12.37 months, p = 0.045, log-rank test). Two distinct transcriptional subclasses of DIPG with specific genomic alterations can be defined at diagnosis by oligodendroglial differentiation or mesenchymal transition, respectively. Classifying these tumors by signal transduction pathway activation and by mutation in pathway member genes may be particularily valuable for the development of targeted therapies.

Collaborating to Cure DIPG

 

DIPG Dad Juan Manuel Viu flew to the U.S. from Spain once again to meet with fellow DIPG Dad, John “Gungie” Rivera at The Cristian Rivera Foundation offices in New York last night.  Dr. Jaume Mora, of Spain’s Hospital Sant Joan de Deu flew into Boston earlier in the week to speak with Dr. Mark Kieran of the Boston Children’s Hospital and Dana Farber Cancer Institute.  The next stop on his trip included a meeting in New York with Dr. Mark Souweidane of Wiell Cornell and Memorial Sloan-Kettering Cancer Center. After speaking with both doctors about recent advancement in DIPG research plans, Dr. Mora met with John “Gungie” Rivera and Juan Manuel Viu at the CRF offices. From there, they enjoyed dinner at Babalu Restaurant in the Bronx to discuss upcoming collaboration to cure DIPG.

Remembering Hope Fuller

 

The Cristian Rivera Foundation remembers DIPG Angel, Hope Fuller who earned her wings on March 10th, 2010 after being diagnosed on July 29th 2009. Hope had a true humanitarian spirit and tried to help everyone in any way she could. From lemonade stands for a homeless woman in her neighborhood and for her school, a car wash for her uncle’s business and donating her hair to Locks of Love, Hope had a huge heart and extended it to help others.  Not only was she extremely intelligent and earned straight As, but she was also very talented in the art of theater, playing the lead of Mulan in a school production.  We aspire to mirror Hope’s compassion and consideration, as she inspires us to do well for everyone around us. Our thoughts are with her family today. Rest in Peaceful Harmony, beautiful angel.